Paley’s Watch Found

There actually is a clock in the heath, and it's in our bodies, too.

Bacteria You Can Love

Wrongly feared only as agents of disease, many bacteria are allies in our quest for health.

Trillions of Helpers in Your Body and Brain

Recent discoveries in human physiology should cause us to stand in awe of the design of our earthly dwelling, especially at the scale of cells.

More Wonders Going On Inside You

Since we all live in a body, we should all feel intrigued with what goes in under our skin. There are more wonders than science can ever fully know.

Body Double: Your Body as a Template for Inventors

Your body contains a lot of things engineers would like to copy, and not just at the scale of C3P0-like humanoid robots.

Cell Chaperones Keep Proteins Properly Folded

Imagine linking together a chain of 300 plastic shapes, some with magnets at various places. Then let it go and see if you could get it to fold spontaneously into a teapot. This is the challenge that cells face every minute: folding long chains of amino acids (polypeptides) into molecular machines and structures for the cell’s numerous tasks required for life. DNA in the nucleus codes for these polypeptides. They are assembled in ribosomes in single-file order. How do they end up in complex folded shapes? Some polypeptides will spontaneously collapse into their native folds, like the magnetic chain in our analogy. Others, however, need help. Fortunately, the cell provides an army of assistants, called chaperones, to monitor, coax, and repair unfolded proteins, to achieve “proteostasis” – a stable, working set of proteins. That army is so well-organized and complex, scientists continue to try to figure out how it performs so well in the field.
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