Evolution predicts gain of function; genetic entropy predicts loss of function. A gene that helps synthesize Vitamin C provides a test between the two views.
“We are all mutants,” proclaimed a headline on Science Daily. “First Direct Whole-Genome Measure of Human Mutation Predicts 60 New Mutations in Each of Us.” The Wellcome Trust Sanger Institute press release reported 60 new mutations per individual, received from parents – a “striking value” the article characterized the “unexpected findings”.